Early antibiotic administration prevents cognitive impairment induced by meningitis in rats

NEUROSCIENCE LETTERS

卷:465

Article

Barichello, Tatiana^1,2  Silva, Geruza Z.²  Batista, Ana L.²  Savi, Geovana D.²  Feier, Gustavo^2,3  Comim, Clarissa M.^2,3  Quevedo, Joao^2,3  Dal-Pizzol, Felipe² 

[1] Univ Extremo Catarinense, UNASAU, PPGCS, Unidade Acad Ciencias Saude,Lab Fisiopatol Expt, BR-88806000 Criciuma, SC, Brazil

[2] Univ Extremo Catarinense, Inst Nacl Ciencia & Tecnol Translac Med, PPGCS, Unidade Acad Ciencias Saude, BR-88806000 Criciuma, SC, Brazil

[3] Univ Extremo Catarinense, Lab Neurociencias, PPGCS, Unidade Acad Ciencias Saude, BR-88806000 Criciuma, SC, Brazil

关键词: Meningitis;    S. pneumoniae;    Memory;    Central nervous system;   

DOI  :  10.1016/j.neulet.2009.08.072

来源: Elsevier

【 摘 要 】

Neurological deficit and alterations in the hippocampus still frequently occur following bacterial meningitis in children, despite the antibiotic treatment. We investigated the long-term outcomes using early versus late antibiotic therapy in experimental pneumococcal meningitis. To this aim, male Wistar rats underwent a basilar cistern tap receiving either sterile saline as a placebo or an equivalent volume of a Streptococcus pneumoniae suspension. Antibiotics were started 8 or 16 h after infection and the animals were followed for 10 days to the determination of long-term cognitive outcomes. The animals were submitted to the habituation of an open-field as an index of long-term cognitive function. Early antibiotic administration (8 h after inoculation) when compared to late antibiotic administration (16 h after inoculation) prevented cognitive impairment induced by pneumococcal meningitis in Wistar rats. The findings from this study suggest that early antibiotic administration is an effective strategy to prevent long-term cognitive impairment in a meningitis animal model. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free