NMDA receptor-mediated calcium entry in the absence of AMPA receptor activation in rat dorsal horn neurons

NEUROSCIENCE LETTERS

卷:204

Article

Reichling, DB ; MacDermott, AB

关键词: magnesium;    spinal cord;    indo-1;    glutamate;    excitatory amino acid;    pain;   

DOI  :  10.1016/0304-3940(96)12305-3

来源: Elsevier

【 摘 要 】

This study tested quantitatively the degree to which selective activation of NMDA receptors increases the intracellular concentration of free Ca2+ ions ([Ca2+](i)) in neurons isolated from the rat spinal cord dorsal horn and grown in culture. The results show that activation of NMDA receptors, without additional depolarizing stimuli, produce [Ca2+](i) increases in the neuronal cell bodies in the presence of physiological concentrations of Mg2+. Furthermore, this phenomenon occurs during synaptic activation of NMDA receptors. Thus, it cannot be assumed that in physiological extracellular [Mg2+], there is an absolute requirement for additional membrane depolarization before NMDA receptor activation stimulates significant increases in [Ca2+](i).

【 授权许可】

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