Perisylvian GABA levels in schizophrenia and bipolar disorder

NEUROSCIENCE LETTERS

卷:637

Article

Atagun, Murat Ilhan^1,2  Sikoglu, Elif Muazzez³  Soykan, Caglar^1,2  Can, Serdar Suleyman^1,2  Ulusoy-Kaymak, Semra²  Caykoylu, Ali^1,2  Algin, Oktay^4,5  Phillips, Mary Louise⁶  Ongur, Dost^7,8  Moore, Constance Mary^3,9 

[1] Ankara Yildirim Beyazit Univ, Dept Psychiat, Sch Med, TR-06800 Ankara, Turkey

[2] Ankara Ataturk Training & Educ Hosp, Dept Psychiat, Ankara, Turkey

[3] Univ Massachusetts, Dept Psychiat, Mem Med Sch, Mem Campus 119 Belmont St, Worcester, MA 01605 USA

[4] Ankara Ataturk Training & Educ Hosp, Dept Radiol, Ankara, Turkey

[5] Bilkent Univ, Natl Magnet Resonance Imaging Res Ctr, Ankara, Turkey

[6] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA

[7] McLean Hosp, Psychot Disorders Div, Belmont, MA USA

[8] Harvard Med Sch, Dept Psychiat, Boston, MA USA

[9] Univ Massachusetts, Sch Med, Dept Radiol, Worcester, MA USA

关键词: Schizophrenia;    Bipolar disorder;    GABA;    Magnetic resonance spectroscopy;    Auditory cortex;   

DOI  :  10.1016/j.neulet.2016.11.051

来源: Elsevier

【 摘 要 】

The aim of this study is to measure GABA levels of perisylvian cortices in schizophrenia and bipolar disorder patients, using proton magnetic resonance spectroscopy (H-1-MRS). Patients with schizophrenia (n = 25), bipolar I disorder (BD-I; n = 28) and bipolar II disorder (BD-II; n = 20) were compared with healthy controls (n = 30). H-1-MRS data was acquired using a Siemens 3 T whole body scanner to quantify right and left perisylvian structures' (including superior temporal lobes) GABA levels. Right perisylvian GABA values differed significantly between groups [chi(2) = 9.62, df: 3, p = 0.022]. GABA levels were significantly higher in the schizophrenia group compared with the healthy control group (p = 0.002). Furthermore, Chlorpromazine equivalent doses of antipsychotics correlated with right hemisphere GABA levels (r(2) = 0.68, p = 0.006, n = 33). GABA levels are elevated in the right hemisphere in patients with schizophrenia in comparison to bipolar disorder and healthy controls. The balance between excitatory and inhibitory controls over the cortical circuits may have direct relationship with GABAergic functions in auditory cortices. In addition, GABA levels may be altered by brain regions of interest, psychotropic medications, and clinical stage in schizophrenia and bipolar disorder. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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