In vivo assessment of neurotransmitters and modulators with magnetic resonance spectroscopy: Application to schizophrenia

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:51

Review

Wijtenburg, S. Andrea¹  Yang, Shaolin^2,3,4  Fischer, Bernard A.^1,7  Rowland, Laura M.^1,5,6 

[1] Univ Maryland, Sch Med, Dept Psychiat, Maryland Psychiat Res Ctr, Baltimore, MD 21228 USA

[2] Univ Illinois, Dept Psychiat, Chicago, IL 60612 USA

[3] Univ Illinois, Dept Radiol, Chicago, IL 60612 USA

[4] Univ Illinois, Dept Bioengn, Chicago, IL 60612 USA

[5] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD 21287 USA

[6] Univ Maryland, Dept Psychol, Baltimore, MD 21228 USA

[7] Vet Affairs Capital Network VISN 5, MIRECC, Dept Vet Affairs, Baltimore, MD 21201 USA

关键词: Magnetic resonance spectroscopy;    Glutamate;    Glutathione;    GABA;    Schizophrenia;   

DOI  :  10.1016/j.neubiorev.2015.01.007

来源: Elsevier

【 摘 要 】

In vivo measurement of neurotransmitters and modulators is now feasible with advanced proton magnetic resonance spectroscopy (H-1 MRS) techniques. This review provides a basic tutorial of MRS, describes the methods available to measure brain glutamate, glutamine, gamma-aminobutyric acid, glutathione, N-acetylaspartylglutamate, glycine, and serine at magnetic field strengths of 3 T or higher, and summarizes the neurochemical findings in schizophrenia. Overall, H-1 MRS holds great promise for producing biomarkers that can serve as treatment targets, prediction of disease onset, or illness exacerbation in schizophrenia and other brain diseases. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

Free