Heat shock protein signaling in brain ischemia and injury

NEUROSCIENCE LETTERS

卷:715

Review

Kim, Jong Youl¹  Kim, Ji Won²  Yenari, Midori A.^3,4 

[1] Yonsei Univ, Coll Med, Dept Anat, Seoul 03722, South Korea

[2] Paichai Univ, Dept Biomed Sci & Biotechnol, Daejeon 35345, South Korea

[3] Univ Calif San Francisco, Dept Neurol, Neurol 127 VAMC 4150 Clement St, San Francisco, CA 94143 USA

[4] San Francisco VA Med Ctr, Neurol 127 VAMC 4150 Clement St, San Francisco, CA 94121 USA

关键词: Heat shock protein 70;    Cerebral ischemic stroke;    Traumatic brain injury;    Neuroprotection;    Pharmacological induction;   

DOI  :  10.1016/j.neulet.2019.134642

来源: Elsevier

【 摘 要 】

Heat shock proteins (HSPs) are chaperones that catalyze the refolding of denatured proteins. In addition to their ability to prevent protein denaturation and aggregation, the HSPs have also been shown to modulate many signaling pathways. Among HSPs, the inducible 70 kDa HSP (HSP70) has especially been shown to improve neurological outcome in experimental models of brain ischemia and injury. HSP70 can modulate various aspects of the programmed cell death pathways and inflammation. This review will focus on potential mechanisms of the neuroprotective effects of HSP70 in stroke and brain trauma models. We also comment on potential ways in which HSP70 could be translated into clinical therapies.

【 授权许可】

Free