Nicotine enhances both foreground and background contextual fear conditioning

NEUROSCIENCE LETTERS

卷:394

Article

Davis, JA ; Porter, J ; Gould, TJ

关键词: learning;    hippocampus;    nicotine;    mice;    acetylcholine;    context;   

DOI  :  10.1016/j.neulet.2005.10.026

来源: Elsevier

【 摘 要 】

The present study examined if nicotine enhances contextual fear conditioning when the training context is either a background stimulus or a foreground stimulus. In the background conditioning experiment, mice were trained using two auditory conditioned stimulus (CS; 30 s, 85 dB white noise)-footshock unconditioned stimulus (US; 2 s, 0.57 mA) pairings and tested 24 h later. In the foreground conditioning experiment, mice were trained with two presentations of a footshock US (2 s, 0.57 mA) and tested 24 h later. Mice received 0.09 mg/kg nicotine before training and testing. For both the foreground and background conditioning experiments, nicotine enhanced contextual conditioning. No enhancement of the auditory CS-US association was seen. These results demonstrate that nicotine enhances contextual fear conditioning regardless of whether the context is a background stimulus or a foreground stimulus during conditioning. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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