RESISTANCE TO NITROPRUSSIDE NEUROTOXICITY IN PERINATAL RAT-BRAIN

NEUROSCIENCE LETTERS

卷:172

Article

MARAGOS, WF ; SILVERSTEIN, FS

关键词: NITRIC OXIDE;    NITROPRUSSIDE;    NEUROTOXICITY;    FREE RADICAL;    PERINATAL;    RODENT;   

DOI  :  10.1016/0304-3940(94)90667-X

来源: Elsevier

【 摘 要 】

Nitric oxide (NO) may mediate some of the toxic effects of the excitatory amino acid (EAA) glutamate when there is overactivation of the N-methyl-D-aspartate (NMDA) receptor. In the developing rodent nervous system, NMDA neurotoxicity peaks at postnatal day 7. To assess whether NO toxicity exhibits a similar developmental profile, we injected the NO generator sodium nitroprusside into the immature and adult rodent hippocampal formation and striatum, using a dose known to damage the adult nervous system. Contrary to our expectations, we found the immature brain highly resistant to the toxic effects of sodium nitroprusside.

【 授权许可】

Free