Hypergolic propellant system of oxidizer MON-25 and fuel MMH has been considered in propulsion trade studies for NASA science mission concepts. A propulsion system using this bi-propellant combination will be capable of operating at a lower temperature as compared to traditional MON-3/MMH for heater power reduction. Operation robustness can also be realized since such a propellant system is utilized under a wide range of temperatures. Propulsion system designs and engine test programs for MON-25/MMH have been carried out since 2008. Several engine development programs have been conducted. The thrust classes of 22-Newton [5-lb(sub f)] and 445-Newton [100-lb(sub f)] were tested with the capability of a pulse mode operation for a wide range of duty cycles. Additional engine development tests are followed. Outcomes of the development efforts suggest that there is a balance of mission benefits and potential engine design and operation challenges, although the propellants can handle a low temperature. This paper will report an assessment of using the MON-25/MMH system for deep- space application.