A 5-HT2C receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference

NEUROSCIENCE LETTERS

卷:505

Article

McCorvy, John D.¹  Harland, Aubrie A.¹  Maglathlin, Rebecca¹  Nichols, David E.¹ 

[1] Purdue Univ, Dept Med Chem & Mol Pharmacol, Coll Pharm, W Lafayette, IN 47907 USA

关键词: Conditioned place preference;    5-HT2C receptor;    Amphetamine;    Dopamine;    Reward;    Drug abuse;   

DOI  :  10.1016/j.neulet.2011.07.036

来源: Elsevier

【 摘 要 】

This study was designed to determine whether a 5-HT2C receptor antagonist could induce a conditioned place preference indicative of reward and/or abuse potential. Here, we present the first evidence that a selective 5-HT2C receptor antagonist, 6-chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide hydrochloride (CEPC), can potentiate a low dose (0.5 mg/kg) amphetamine-induced positive conditioned place preference (CPP). CEPC did not produce any CPP given alone at doses of either 2.0 or 4.0 mg/kg, whereas low dose amphetamine alone produced only a slight, but statistically nonsignificant, place preference. These studies suggest that 5-HT2C receptor antagonists can indirectly potentiate the rewarding effects of amphetamine, and perhaps other psychostimulants. If the results can be translated to man, putative 5-HT2C receptor antagonist treatments for anxiety or depression may enhance or potentiate the rewarding effects of drugs of abuse such as amphetamine, which release dopamine. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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