Dendritic spine alterations in schizophrenia

NEUROSCIENCE LETTERS

卷:601

Review

Moyer, Caitlin E.¹  Shelton, Micah A.¹  Sweet, Robert A.^1,2,3 

[1] Univ Pittsburgh, Dept Psychiat, Translat Neurosci Program, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15213 USA

[3] VA Pittsburgh Healthcare Syst, VISN Mental Illness Res Educ & Clin Ctr MIRECC 4, Pittsburgh, PA 15206 USA

关键词: Schizophrenia;    Dendritic spine;    Postmortem;    Adolescence;    MAP2;    Kalirin;   

DOI  :  10.1016/j.neulet.2014.11.042

来源: Elsevier

【 摘 要 】

Schizophrenia is a chronic illness affecting approximately 0.5-1% of the world's population. The etiology of schizophrenia is complex, including multiple genes, and contributing environmental effects that adversely impact neurodevelopment. Nevertheless, a final common result, present in many subjects with schizophrenia, is impairment of pyramidal neuron dendritic morphology in multiple regions of the cerebral cortex. In this review, we summarize the evidence of reduced dendritic spine density and other dendritic abnormalities in schizophrenia, evaluate current data that informs the neurodevelopment timing of these impairments, and discuss what is known about possible upstream sources of dendritic spine loss in this illness. Published by Elsevier Ireland Ltd.

【 授权许可】

Free