Inactivation of the prelimbic rather than infralimbic cortex impairs acquisition and expression of formalin-induced conditioned place avoidance

NEUROSCIENCE LETTERS

卷:569

Article

Jiang, Zhao-Cai^1,2  Pan, Qi³  Zheng, Chun^1,2,4  Deng, Xiao-Fei^1,2  Wang, Jin-Yan¹  Luo, Fei¹ 

[1] Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100039, Peoples R China

[3] Southern Med Univ, Zhujiang Hosp, Dept Neurosurg, Guangzhou 510282, Guangdong, Peoples R China

[4] Southwest Univ Nationalities, Dept Psychol, Chengdu 610041, Peoples R China

关键词: Prefrontal cortex;    Conditioned place avoidance;    Acquisition;    Expression;    Pain emotion;    Rats;   

DOI  :  10.1016/j.neulet.2014.03.074

来源: Elsevier

【 摘 要 】

Conditioned place avoidance (CPA) paradigm has been used to investigate the affective component of pain. Although the anterior cingulate cortex (ACC) has been demonstrated to play an important role in the affective aspect of pain, whether the other prefrontal subdivisions are involved in pain-related aversion is unknown. The present study investigated the role of the prelimbic cortex (PL) and infralimbic cortex (IL) in the acquisition and expression of formalin-induced CPA (F-CPA) in rats. GABA(A) receptor agonist muscimol was bilaterally microinjected into PL/IL before or after the formalin-paired training, to explore the effect of temporary inactivation of PL/IL on the acquisition and expression of F-CPA, respectively. The results showed that inactivation of PL rather than IL impaired the acquisition and expression of F-CPA. Moreover, the PL inactivation did not block the acquisition of LiCl-induced CPA, suggesting that PL may be specifically implicated in the pain-emotion related encoding. These results indicate that PL but not IL is involved in the aversive dimension of pain. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free