Social stress increases expression of hemoglobin genes in mouse prefrontal cortex

BMC Neuroscience

Paweł Lisowski¹  Grzegorz R Juszczak³  Marek Wieczorek⁶  Alicja Majewska⁴  Artur H Swiergiel⁵  Joanna Goscik²  Adrian M Stankiewicz³ 

[1] iPS Cell-Based Disease Modeling Group, Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, 13092, Germany;Faculty of Computer Science, Bialystok University of Technology, Wiejska 45A, Bialystok, 15-351, Poland;Department of Animal Behavior, Institute of Genetics and Animal Breeding, Jastrzebiec, ul. Postepu 36A, Magdalenka, 05-552, Poland;Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland;Department of Human and Animal Physiology, Institute of Biology, University of Gdansk, Gdansk, 80-308, Poland;Department of Neurobiology, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Pomorska 141/143, Poland

关键词: Social stress;    Prefrontal cortex;    Expression;    Gene;    Microarray;   

Others  :  1090334
DOI  :  10.1186/s12868-014-0130-6

 received in 2014-05-10, accepted in 2014-11-18,  发布年份 2014

【 摘 要 】

Background

In order to better understand the effects of social stress on the prefrontal cortex, we investigated gene expression in mice subjected to acute and repeated social encounters of different duration using microarrays.

Results

The most important finding was identification of hemoglobin genes (Hbb-b1, Hbb-b2, Hba-a1, Hba-a2, Beta-S) as potential markers of chronic social stress in mice. Expression of these genes was progressively increased in animals subjected to 8 and 13 days of repeated stress and was correlated with altered expression of Mgp (Mglap), Fbln1, 1500015O10Rik (Ecrg4), SLC16A10, and Mndal. Chronic stress increased also expression of Timp1 and Ppbp that are involved in reaction to vascular injury. Acute stress did not affect expression of hemoglobin genes but it altered expression of Fam107a (Drr1) and Agxt2l1 (Etnppl) that have been implicated in psychiatric diseases.

Conclusions

The observed up-regulation of genes associated with vascular system and brain injury suggests that stressful social encounters may affect brain function through the stress-induced dysfunction of the vascular system.

【 授权许可】

   
2014 Stankiewicz et al.; licensee BioMed Central Ltd.

【 图 表 】

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