Chewing suppresses the stress-induced increase in the number of pERK-immunoreactive cells in the periaqueductal grey

NEUROSCIENCE LETTERS

卷:599

Article

Yamada, Kentaro¹  Narimatsu, Yuri²  Ono, Yumie³  Sasaguri, Ken-Ichi⁴  Onozuka, Minoru⁵  Kawata, Toshitsugu²  Yamamoto, Toshiharu¹ 

[1] Kanagawa Dent Univ, Dept Oral Sci, Div Brain Funct & Neurosci, Yokosuka, Kanagawa 2388580, Japan

[2] Kanagawa Dent Univ, Dept Oral Sci, Div Orthodont, Yokosuka, Kanagawa 2388580, Japan

[3] Meiji Univ, Sch Sci & Technol, Dept Elect & Bioinformat, Kawasaki, Kanagawa, Japan

[4] Jichi Med Univ, Dept Oral Surg, Shimotsuke, Japan

[5] Nittai Jyusei Med Coll Judo Therapeut, Tokyo, Japan

关键词: Chewing;    Immobilization stress;    Periaqueductal gray;    Phosphorylated kinase;    Rat;   

DOI  :  10.1016/j.neulet.2015.05.023

来源: Elsevier

【 摘 要 】

We investigated the effects of chewing under immobilization stress on the periaqueductal gray (PAG) matter using phosphorylated extracellular signal-regulated kinase (pERK) as a marker of responding cells. Immobilization stress increased pERK-immunoreactive cells in the PAG. Among four subdivisions of the PAG, the increase of immunoreactive cells was remarkable in the dorsolateral and ventrolateral subdivisions. However, increase of pERK-immunoreactive cells by the immobilization stress was not so evident in the dorsomedial and lateral subdivisions. The chewing under immobilization stress prevented the stress-induced increase of pERK-immunoreactive cells in the dorsolateral and ventrolateral subdivisions with statistical significances (p < 0.05). Again, chewing effects on pERK-immunoreactive cells were not visible in the dorsomedial and lateral subdivisions. These results suggest that the chewing alleviates the PAG (dorsolateral and ventrolateral subdivisions) responses to stress. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free