Chewing augments stress-induced increase of pERK-immunoreactive cells in the rat cingulate cortex

NEUROSCIENCE LETTERS

卷:727

Article

Hatanaka, Reina¹  Onuki, Masami¹  Sasaguri, Kenichi²  Yamada, Kentaro²  Saruta, Juri³  Yamamoto, Toshiharu⁴ 

[1] Kanagawa Dent Univ, Grad Sch Dent, Dept Oral Sci, Orthodont Div, Inaoka Cho 82, Yokosuka, Kanagawa 2388580, Japan

[2] Jichi Med Univ Hosp, Dept Oral Surg, Yakushiji 3311-1, Shimotsuke, Tochigi 3290498, Japan

[3] Kanagawa Dent Univ, Grad Sch Dent, Dept Oral Sci, Environm Pathol Div, Inaoka Cho 82, Yokosuka, Kanagawa, Japan

[4] Kanagawa Dent Univ, Grad Sch Dent, Dept Oral Sci, Brain Funct & Neurosci Div, Inaoka Cho 82, Yokosuka, Kanagawa 2388580, Japan

关键词: Chewing;    Cingulate cortex;    Immobilization stress;    pERK1/2;    Rat;   

DOI  :  10.1016/j.neulet.2020.134921

来源: Elsevier

【 摘 要 】

The eff;ects of chewing during restraint stress on the anterior, mid- and posterior cingulate cortices were investigated in rats using immunohistochemistry to detect the expression of phosphorylated extracellular signal-regulated kinase 1 and 2 (pERK1/2), a marker of responding cells. The rats were divided into three groups: control (no immobilization), stress-only (immobilized), and stress-with-chewing (immobilized and allowed to chew a wooden stick). Significant increases in the number of pERK1/2-immunoreactive cells in the anterior, mid- and posterior cingulate cortices were noted in the stress-only group when compared with the control group (p<0.05). Furthermore, the number of pERK1/2-immunoreactive cells in the anterior, mid- and posterior cingulate cortices in the stress-with-chewing group was also significantly higher than that in the stress-only group (p<0.05). These findings indicate that the cingulate cortex plays a role in the negative-feedback effect and might be an essential part of the brain where the ameliorating effects of chewing against stress are produced.

【 授权许可】

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