Increased regional gray matter atrophy and enhanced functional connectivity in male multiple sclerosis patients

NEUROSCIENCE LETTERS

卷:630

Article

Sanchis-Segura, C.¹  Cruz-Gomez, A. J.¹  Belenguer, A.²  Fittipaldi Marquez, M. S.¹  Avila, C.¹  Forn, C.¹ 

[1] Univ Jaume 1, Dept Psicol Basica Clin & Psicobiol, Castellon de La Plana, Spain

[2] Hosp Gen Castellon, Serv Neurol, Castellon de La Plana, Spain

关键词: Multiple sclerosis;    Gender;    Cognition;    Magnetic resonance imaging;    Voxel-based morphometry;    Functional connectivity;   

DOI  :  10.1016/j.neulet.2016.07.028

来源: Elsevier

【 摘 要 】

Evidence suggests that sex/gender is an important factor for understanding multiple sclerosis (MS) and that some of its neuropathological consequences might manifest earlier in males. In the present study, we assessed gray matter (GM) volume and functional connectivity (FC) in a sample of female and male MS patients (MSp) and female and male healthy controls (HCs). As compared to female MSp, male MSp showed decreased GM volume in the bilateral frontal areas and increased FC between different brain regions. Because both sets of changes correlated significantly and no differences in cognitive performance were observed, we suggest that the FC increase observed in male MSp acts as a compensatory mechanism for their more extensive GM loss and that it promotes a functional convergence between male- and female-MSp. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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