Increased plasma levels of brain derived neurotrophic factor (BDNF) after multiple sclerosis relapse

NEUROSCIENCE LETTERS

卷:460

Article

Comini Frota, Elizabeth Regina¹  Rodrigues, David Henrique²  Donadi, Eduardo Antonio³  Brum, Doralina G.⁴  Kaimen Maciel, Damacio Ramon⁵  Teixeira, Antonio Lucio^1,2,6 

[1] Univ Fed Minas Gerais, Univ Hosp, Neurol Unit, BR-30130100 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Inst Biol Sci, Lab Immunopharmacol, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Sao Paulo, Div Immunol, Dept Med, Sch Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil

[4] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Neurol, BR-14049900 Ribeirao Preto, SP, Brazil

[5] Univ Estadual Londrina, Hlth Sci Ctr, Dept Med, BR-86038440 Londrina, PR, Brazil

[6] Univ Fed Minas Gerais, Sch Med, Dept Internal Med, BR-30130100 Belo Horizonte, MG, Brazil

关键词: Neurotrophins;    Brain derived neurotrophic factor;    Multiple sclerosis;    Neuroprotection;   

DOI  :  10.1016/j.neulet.2009.05.057

来源: Elsevier

【 摘 要 】

Brain derived neurotrophic factor (BDNF) has been related to neuroprotection in a series of central nervous system diseases, although its role in multiple sclerosis (MS) was only partially investigated. In this work, we aimed to evaluate the plasma levels of BDNF from 29 MS patients and 24 control subjects. MS patients had decreased levels of BDNF in comparison with healthy controls. BDNF levels increased significantly after MS relapse. Our results provide some evidence for the involvement of BDNF in the pathogenesis of MS and suggest a role for this neurotrophin during the recovery of acute demyelinating inflammatory lesion. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free