A discrete event system specification (DEVS)-based model of consanguinity

JOURNAL OF THEORETICAL BIOLOGY

卷:285

Article

Akhtar, Noreen¹  Niazi, Muaz^1,2  Mustafa, Farah¹  Hussain, Amir² 

[1] COMSATS Inst IT, Dept Biosci, Islamabad, Pakistan

[2] Univ Stirling, Dept Comp Sci & Math, Stirling FK9 4LA, Scotland

关键词: Consanguineous marriages;    Simulation;    Congenital disorder;    Complex systems;    DEVS formalism;   

DOI  :  10.1016/j.jtbi.2011.05.038

来源: Elsevier

【 摘 要 】

Consanguinity or inter-cousin marriage is a phenomenon quite prevalent in certain regions around the globe. Consanguineous parents have a higher risk of having offspring with congenital disorders. It is difficult to model large scale consanguineous parental populations because of disparate cultural issues unique to regions and cultures across the globe. Although consanguinity has previously been studied as a social problem, it has not been modeled from a biological perspective. Discrete event system specification (DEVS) is a powerful modeling formalism for the study of intricate details of real-world complex systems. In this paper, we have developed a DEVS model to get an insight into the role of consanguineous marriages in the evolution of congenital disorders in a population. As proof-of-concept, we further developed a consanguinity simulation model in Simio simulation software. Simulation results validated using population growth data show the effectiveness of this approach in the modeling of consanguinity in populations. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

Free