Synaptotagmins 1 and 2 as mediators of rapid exocytosis at nerve terminals: The dyad hypothesis

JOURNAL OF THEORETICAL BIOLOGY

卷:332

Article

Gundersen, Cameron B.¹  Umbach, Joy A.¹ 

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

关键词: Membrane fusion;    SNAREs;    Cysteine string proteins;    C2 domains;    Protein palmitoylation;   

DOI  :  10.1016/j.jtbi.2013.04.029

来源: Elsevier

【 摘 要 】

The dyad model was developed to explain the extremely rapid kinetics of synaptic vesicle exocytosis. In contrast to most hypotheses which invoke interactions among synaptotagmins, SNAREs and other regulatory molecules, the dyad model features a quartet of synaptotagmins arrayed at the synaptic vesicle plasma membrane interface. Ca2+-triggered movements of these synaptotagmins initiate a sequence of events culminating in the fusion of the vesicular and plasma membranes. The relative simplicity of this model and its amenability to empirical testing provide a useful template for future investigations of the molecular events underlying the exocytotic cascade. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

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