Stochastic modeling reveals how motor protein and filament properties affect intermediate filament transport

JOURNAL OF THEORETICAL BIOLOGY

卷:464

Article

Dallon, J. C.¹  Leduc, Cecile²  Etienne-Manneville, Sandrine²  Portet, Stephanie³ 

[1] Brigham Young Univ, Dept Math, 344 TMCB, Provo, UT 84602 USA

[2] Inst Pasteur Paris, Cell Polar Migrat & Canc Unit, Equipe Labellisee Ligue Canc, CNRS UMR3691, 25 Rue Dr Roux, F-75724 Paris 15, France

[3] Univ Manitoba, Dept Math, Winnipeg, MB, Canada

关键词: Intermediate filaments;    Dynein;    Kinesin;    Vimentin;    Molecular motors;    Stochastic;   

DOI  :  10.1016/j.jtbi.2018.12.022

来源: Elsevier

【 摘 要 】

Intermediate filaments are a key component of the cytoskeleton. Their transport along microtubules plays an essential role in the control of the shape and structural organization of cells. To identify the key parameters responsible for the control of intermediate filament transport, we generated a model of elastic filament transport by microtubule-associated dynein and kinesin. The model is also applicable to the transport of any elastically-coupled cargoes. We investigate the effect of filament properties such as number of motor binding sites, length, and elasticity on motion of filaments. Additionally, we consider the effect of motor properties, i.e. off rates, on filament transport. When one motor has a catch bond off rate it dictates the motion, whereas when motors have the same type of off rate filaments can alternate between retrograde and anterograde motions. The elasticity of filaments optimizes the filament transport and the coordination of motors along the length of the filament. (C) 2018 Elsevier Ltd. All rights reserved.

【 授权许可】

Free