Possible mechanisms of bidirectional nuclear transport during neuronal migration

Biocell

article

CHUYING ZHOU¹  MINEKO KENGAKU¹ 

[1] Graduate School of Biostudies, Kyoto University;Institute for Integrated Cell-Material Sciences ,(WPI-iCeMS), Kyoto University

关键词: Nesprin-2;    Nucleus;    Microtubules;    Kinesin;    Dynein;   

DOI  :  10.32604/biocell.2022.021050

学科分类：仪器

来源: Biocell

【 摘 要 】

Neuronal migration is a fundamental process of mammalian brain development. In migrating neurons, the nuclear membrane protein Nesprin-2 has been shown to serve as an adaptor to pull the nucleus along microtubule tracks. Current evidence has shown that Nesprin-2 binds to both the minus-end-directed motor dynein as well as the plus-end-directed motor kinesin. However, translocation of neuronal nucleus has long been thought to be primarily driven by dynein motors. Intriguing questions could be raised about the role of kinesin in nuclear transport and how the activities of opposing motors are coordinated through interactions with Nesprin. Combining evidence from recent studies, we propose that Nesprin-2 serves as a switchboard in mediating bidirectional neuronal nuclear movements.

【 授权许可】

CC BY