Modeling sphingomyelin synthase 1 driven reaction at the Golgi apparatus can explain data by inclusion of a positive feedback mechanism

JOURNAL OF THEORETICAL BIOLOGY

卷:337

Article

Thomaseth, Caterina¹  Weber, Patrick¹  Hamm, Thomas¹  Kashima, Kenji²  Radde, Nicole¹ 

[1] Univ Stuttgart, Inst Syst Theory & Automat Control, D-70569 Stuttgart, Germany

[2] Osaka Univ, Dept Syst Innovat, Grad Sch Engn Sci, Tokyonaka, Osaka 5608531, Japan

关键词: Feedback control;    Sphingomyelin synthase 1;    Sphingomyelin synthesis;   

DOI  :  10.1016/j.jtbi.2013.08.022

来源: Elsevier

【 摘 要 】

Here we present a minimal mathematical model for the sphingomyelin synthase 1 (SMS1) driven conversion of ceramide to sphingomyelin based on chemical reaction kinetics. We demonstrate via mathematical analysis that this model is not able to qualitatively reproduce experimental measurements on lipid compositions after altering SMS1 activity. We prove that a positive feedback mechanism from the products to the reactants of the reaction is one possible model extension to explain these specific experimental data. The proposed mechanism in fact exists in vivo via protein kinase D and the ceramide transfer protein CERT. The model is further evaluated by additional observations from the literature. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free