Individual cell-based models of cell scatter of ARO and MLP-29 cells in response to hepatocyte growth factor

JOURNAL OF THEORETICAL BIOLOGY

卷:260

Article

Scianna, Marco^1,4,5  Merks, Roeland M. H.^2,3  Preziosi, Luigi¹  Medico, Enzo^4,5 

[1] Politecn Torino, Dept Math, I-10129 Turin, Italy

[2] NCSB NISB, NL-1098 XG Amsterdam, Netherlands

[3] CWI, NL-1090 GB Amsterdam, Netherlands

[4] Univ Turin, Sch Med, Inst Canc Res, Lab Oncogenom, I-10060 Candiolo, Italy

[5] Univ Turin, Sch Med, Dept Oncol Sci, I-10060 Candiolo, Italy

关键词: Cellular Potts model;    Hepatocyte growth factor;    ARO cell line;    Cell-cell dissociation;    Invasive growth;    MLP-29 cell line;    Scattering;   

DOI  :  10.1016/j.jtbi.2009.05.017

来源: Elsevier

【 摘 要 】

The different behaviors of colonies of two cell lines, ARO (thyroid carcinoma-derived cells) and MLP-29 (mouse liver progenitor cells), in response to hepatocyte growth factor(HGF) are described deducing suitable cellular Potts models (CPM). It is shown how increased motility and decreased adhesiveness are responsible for cell-cell dissociation and tissue invasion in the ARO cells. On the other hand, it is shown that, in addition to the biological mechanisms above, it is necessary to include directional persistence in cell motility and HGF diffusion to describe the scattering and the branching processes characteristic of MLP-29 cells. (C) 2009 Elsevier Ltd. All rights reserved.

【 授权许可】

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