Resistance to genetic insect control: Modelling the effects of space

JOURNAL OF THEORETICAL BIOLOGY

卷:413

Article

Watkinson-Powell, Benjamin^1,3  Alphey, Nina^1,2 

[1] Imperial Coll London, Dept Life Sci, Silwood Pk Campus,Buckhurst Rd, Ascot SL5 7PY, Berks, England

[2] Univ Oxford, Dept Zool, Math Ecol Res Grp, South Parks Rd, Oxford OX1 3PS, England

[3] Univ Cambridge, Dept Plant Sci, Downing St, Cambridge CB2 3EA, England

关键词: Pest insects;    Self-limiting RIDL;    Sterile insect technique (SIT);    Mathematical modelling;    Spatial dynamics;   

DOI  :  10.1016/j.jtbi.2016.10.014

来源: Elsevier

【 摘 要 】

Genetic insect control, such as self-limiting RIDL2 (Release of Insects Carrying a Dominant Lethal) technology, is a development of the sterile insect technique which is proposed to suppress wild populations of a number of major agricultural and public health insect pests. This is achieved by mass rearing and releasing male insects that are homozygous for a repressible dominant lethal genetic construct, which causes death in progeny when inherited. The released genetically engineered ('GE') insects compete for mates with wild individuals, resulting in population suppression. A previous study modelled the evolution of a hypothetical resistance to the lethal construct using a frequency-dependent population genetic and population dynamic approach. This found that proliferation of resistance is possible but can be diluted by the introgression of susceptible alleles from the released homozygous-susceptible GE males. We develop this approach within a spatial context by modelling the spread of a lethal construct and resistance trait, and the effect on population control, in a two deme metapopulation, with GE release in one deme. Results show that spatial effects can drive an increased or decreased evolution of resistance in both the target and non-target demes, depending on the effectiveness and associated costs of the resistant trait, and on the rate of dispersal. A recurrent theme is the potential for the non target deme to act as a source of resistant or susceptible alleles for the target deme through dispersal. This can in turn have a major impact on the effectiveness of insect population control.

【 授权许可】

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