An elasto-visco-plastic model of cell aggregates

JOURNAL OF THEORETICAL BIOLOGY

卷:262

Article

Preziosi, L.¹  Ambrosi, D.²  Verdier, C.^3,4 

[1] Politecn Torino, Dept Math, I-10129 Turin, Italy

[2] Politecn Milan, MOX Dipartimento Matemat, I-20131 Milan, Italy

[3] CNRS, Spectrometrie Phys Lab, UMR 5588, F-38402 St Martin Dheres, France

[4] Univ Grenoble 1, F-38402 St Martin Dheres, France

关键词: Cancer modelling;    Continuum mechanics;    Constitutive equation;    Tissue mechanics;   

DOI  :  10.1016/j.jtbi.2009.08.023

来源: Elsevier

【 摘 要 】

Concentrated cell suspensions exhibit different mechanical behavior depending on the mechanical stress or deformation they undergo. They have a mixed theological nature: cells behave elastically or viscoelastically, they can adhere to each other whereas the carrying fluid is usually Newtonian. We report here on a new elasto-visco-plastic model which is able to describe the mechanical properties of a concentrated cell suspension or aggregate. It is based on the idea that the rearrangement of adhesion bonds during the deformation of the aggregate is related to the existence of a yield stress in the macroscopic constitutive equation. We compare the predictions of this new model with five experimental tests: steady shear rate, oscillatory shearing tests, stress relaxation, elastic recovery after steady prescribed deformation, and uniaxial compression tests. All of the predictions of the model are shown to agree with these experiments. (C) 2009 Elsevier Ltd. All rights reserved.

【 授权许可】

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