Memory versus effector immune responses in oncolytic virotherapies

JOURNAL OF THEORETICAL BIOLOGY

卷:377

Article

Macnamara, Cicely¹  Eftimie, Raluca¹ 

[1] Univ Dundee, Div Math, Dundee DD1 4HN, Scotland

关键词: Cancer modelling;    Effector and memory cells;    Tumour control;    Tumour dormancy;   

DOI  :  10.1016/j.jtbi.2015.04.004

来源: Elsevier

【 摘 要 】

The main priority when designing cancer immuno-therapies has been to seek viable biological mechanisms that lead to permanent cancer eradication or cancer control. Understanding the delicate balance between the role of effector and memory cells on eliminating cancer cells remains an elusive problem in immunology. Here we make an initial investigation into this problem with the help of a mathematical model for oncolytic virotherapy; although the model can in fact be made general enough to be applied also to other immunological problems. According to this model, we find that long-term cancer control is associated with a large number of persistent effector cells (irrespective of the initial peak in effector cell numbers). However, this large number of persistent effector cells is sustained by a relatively large number of memory cells. Moreover, the results of the mathematical model suggest that cancer control from a dormant state cannot be predicted by the size of the memory population. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

Free