Autophagy: A housekeeper in cardiorenal metabolic health and disease

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1852

Review

Jia, Guanghong^1,2,3,4,7  Sowers, James R.^{1,2,3,4,5,6,7} 

[1] Univ Missouri, Sch Med, Diabet Cardiovasc Ctr, Div Endocrinol, Columbia, MO USA

[2] Univ Missouri, Sch Med, Diabet Cardiovasc Ctr, Div Diabet, Columbia, MO USA

[3] Univ Missouri, Sch Med, Diabet Cardiovasc Ctr, Div Hypertens, Columbia, MO USA

[4] Univ Missouri, Sch Med, Diabet Cardiovasc Ctr, Div Metab, Columbia, MO USA

[5] Univ Missouri, Sch Med, Dept Med Pharmacol, Columbia, MO USA

[6] Univ Missouri, Sch Med, Dept Physiol, Columbia, MO 65212 USA

[7] Univ Missouri, Sch Med, Harry S Truman Mem Vet Hosp, Columbia, MO USA

关键词: Autophagy;    Cardiorenal metabolic syndrome;    Insulin resistance;    Obesity;    Endoplasmic reticulum stress;    Reactive oxygen species;   

DOI  :  10.1016/j.bbadis.2014.06.025

来源: Elsevier

【 摘 要 】

Autophagy, literally translated means self-eating, is a primary degradative pathway and plays an important role in the regulation of cellular homeostasis through elimination of aggregated proteins, damaged organelles, and intracellular pathogens. Autophagy has been classified into microautophagy, macroautophagy, and chaperonemediated autophagy, depending on the choice of the pathway by which the cellular material is delivered to lysosomes. Dysregulation of autophagy may contribute to the development of cardiorenal metabolic syndrome (CRS), including insulin resistance, obesity, hypertension, maladaptive immune modulation, and associated cardiac and renal disease. Clarifying the pathways and mechanisms of autophagy under normal conditions is essential to understanding its dysregulation in the development of CRS. Here, we highlight a recent surge in autophagy research, such as the cellular quality control through the disposal and recycling of cellular components, and summarize our contemporary understanding of molecular mechanisms of autophagy in diverse organ or tissues involved in the pathogenesis of CRS. This article is part of a Special Issue entitled: Autophagy and protein quality control in cardiometabolic diseases. (C) 2014 Published by Elsevier B.V.

【 授权许可】

Free