Intracerebral hemorrhage and cognitive impairment

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1862

Article

Xiong, Li^1,2  Reijmer, Yael D.¹  Charidimou, Andreas¹  Cordonnier, Charlotte³  Viswanathan, Anand¹ 

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, J Philip Kistler Stroke Res Ctr, Boston, MA 02114 USA

[2] Wuhan Univ, Zhongnan Hosp, Dept Neurol, Wuhan 430071, Peoples R China

[3] Lille Univ Hosp, Hop Roger Salengro, Dept Neurol & Stroke Unit, F-59037 Lille, France

关键词: Intracerebral hemorrhage;    Cognitive impairment;    Dementia;    Small vessel disease;    Neurodegenerative pathology;   

DOI  :  10.1016/j.bbadis.2015.12.011

来源: Elsevier

【 摘 要 】

Vascular cognitive impairment and vascular dementia are composed of cognitive deficits resulted from a range of vascular lesions and pathologies, including both ischemic and hemorrhagic. However the contribution of spontaneous intracerebral hemorrhage presumed due to small vessel diseases on cognitive impairment is underestimated, in contrast to the numerous studies about the role of ischemic vascular disorders on cognition. In this review we summarize recent findings from clinical studies and appropriate basic science research to better elucidate the role and possible mechanisms of intracerebral hemorrhage in cognitive impairment and dementia. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock. (c) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

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