The influence of exercise on brain aging and dementia

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1822

Review

Lautenschlager, Nicola T.^1,2,3  Cox, Kay⁴  Cyarto, Elizabeth V.⁵ 

[1] Univ Melbourne, St Georges Hosp, Dept Psychiat, Acad Unit Psychiat Old Age, Kew, Vic 3103, Australia

[2] Univ Western Australia, WA Ctr Hlth & Ageing, Perth, WA 6009, Australia

[3] Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia

[4] Univ Western Australia, Royal Perth Hosp Unit, Sch Med & Pharmacol, Perth, WA 6009, Australia

[5] Natl Ageing Res Inst, Melbourne, Vic, Australia

关键词: Physical activity;    Exercise;    Cognition;    Cognitive impairment;    Dementia;    Alzheimer's disease;   

DOI  :  10.1016/j.bbadis.2011.07.010

来源: Elsevier

【 摘 要 】

Physical activity has been recognized as an important protective factor reducing disability and mortality and therefore it is focus of many health promotion activities at all ages. More recently a growing body of literature is focusing whether physical activity could also have a positive impact on brain aging with exploring healthy brain aging as well as on cognitive impairment and dementia. An increasing number of prospective studies and randomized controlled trials involving humans take place both with older adults with normal cognition as well as with mild cognitive impairment or dementia. However, the body of evidence is still sparse and many methodological issues make comparisons across studies challenging. Increasingly research into underlying mechanisms in relation to physical activity and brain aging identify biomarker candidates with especially neuroimaging measurements being more used in trials with humans. Whilst the evidence base is slowly growing more detailed research is needed to address methodological issues to finally achieve clinical relevance. This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease. (C) 2011 Published by Elsevier B.V.

【 授权许可】

Free