Glial influences on BBB functions and molecular players in immune cell trafficking

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1862

Article

Lecuyer, Marc-Andre¹  Kebir, Hania¹  Prat, Alexandre^1,2,3 

[1] Ctr Hosp Univ Montreal, Ctr Rech, Neuroimmunol Res Lab, Montreal, PQ, Canada

[2] CHUM, Notre Dame Hosp, Div Neurol, Multiple Sclerosis Clin, Montreal, PQ H2X 0A9, Canada

[3] Univ Montreal, Fac Med, Dept Neurosci, Montreal, PQ H3C 3J7, Canada

关键词: Blood-brain barrier (BBB);    Neurovascular unit (NVU);    Neuroinflammation;    Glial cells;    Astrocytes;    Endothelial cells;    Microglia;    Multiple sclerosis (MS);    Experimental autoimmune encephalomyelitis (EAE);    Tight junction molecules;    IL-17;   

DOI  :  10.1016/j.bbadis.2015.10.004

来源: Elsevier

【 摘 要 】

The blood-brain barrier (BBB) constitutes an elaborate structure formed by specialized capillary endothelial cells, which together with pericytes and perivascular glial cells regulates the exchanges between the central nervous system (CNS) and the periphery. Intricate interactions between the different cellular constituents of the BBB are crucial in establishing a functional BBB and maintaining the delicate homeostasis of the CNS microenvironment. In this review, we discuss the role of astrocytes and microglia in inducing and maintaining barrier properties under physiological conditions as well as their involvement during neuroinflammatory pathologies. This article is part of a Special Issue entitled: Neuro Inflammation edited by Helga E. de Vries and Markus Schwaninger. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

Free