Type 2 diabetes mellitus, hypertension, dyslipidemia and obesity: A systematic comparison of their impact on cognition

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1792

Review

van den Berg, Esther¹  Kloppenborg, Raoul P.²  Kessels, Roy P. C.^3,4,5,6  Kappelle, L. Jaap¹  Biessels, Geert Jan¹ 

[1] Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Neurol, NL-3508 GA Utrecht, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Dept Neurol, NL-1105 AZ Amsterdam, Netherlands

[3] Univ Utrecht, Helmholtz Inst, Dept Expt Psychol, Utrecht, Netherlands

[4] Radboud Univ Nijmegen, Nijmegen Inst Cognit & Informat, NL-6525 ED Nijmegen, Netherlands

[5] Radboud Univ Nijmegen, Med Ctr, Donders Ctr Neurosci, Dept Geriatr, NL-6525 ED Nijmegen, Netherlands

[6] Radboud Univ Nijmegen, Med Ctr, Donders Ctr Neurosci, Dept Med Psychol, NL-6525 ED Nijmegen, Netherlands

关键词: Cognitive functioning;    Learning;    Memory;    Executive functioning;    Vascular risk factor;    Diabetes;    Hypertension;    Dyslipidemia;    Obesity;    Epidemiology;   

DOI  :  10.1016/j.bbadis.2008.09.004

来源: Elsevier

【 摘 要 】

Vascular risk factors, such as type 2 diabetes mellitus, hypertension, dyslipidemia and obesity, have been associated with an increased risk of cognitive dysfunction, particularly in the elderly. The aim of this systematic review was to compare these risk factors with regard to the nature and magnitude of the associated cognitive decrements. Cross-sectional and longitudinal studies that assessed cognitive functioning in non-demented persons in relation to diabetes/impaired glucose metabolism (k=36), hypertension (k=24), dyslipidemia (k=7) and obesity (k=6) and that adjusted or matched for age, gender and education were included. When possible, effect sizes (Cohen's d) were computed per cognitive domain. Diabetes and hypertension were clearly associated with cognitive decrements; the results for obesity and dyslipidemia were less consistent. Effect sizes were moderate (median similar to -0.3) for all risk factors. Decline was found in all cognitive domains, although the effects on cognitive speed, mental flexibility and memory were most consistent. Methodological aspects of included studies and implications of these findings are discussed. (C) 2008 Elsevier B.V. All rights reserved.

【 授权许可】

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