Dietary manipulation and caloric restriction in the development of mouse models relevant to neurological diseases

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1802

Review

Richardson, Jill C.¹ 

[1] GlaxoSmithKline, R&D China, Neurosci CEDD, Harlow CM19 5AW, Essex, England

关键词: Alzheimer's disease;    Diabetes;    Insulin resistance;    Calorie restriction;    Neurodegeneration;    Ageing;   

DOI  :  10.1016/j.bbadis.2010.04.007

来源: Elsevier

【 摘 要 】

Manipulation of diet such as increasing the level of fat or inducing insulin resistance has been shown to exacerbate the pathology in several animal models of neurological disease. Caloric restriction, however, has been demonstrated to extend the life span of many organisms. Reduced calorie consumption appears to increase the resistance of neurons to intracellular and extracellular stress and consequently improves the behavioural phenotype in animal models of neurological diseases, such as Alzheimer's disease. We review the evidence from a variety of mouse models that diet is a risk factor that can significantly contribute to the development of neurological diseases. (C) 2010 Elsevier B.V. All rights reserved.

【 授权许可】

Free