TGF-β and fibrosis in different organs - molecular pathway imprints

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1792

Review

Pohlers, Dirk¹  Brenmoehl, Julia²  Loeffler, Ivonne³  Mueller, Cornelia K.⁴  Leipner, Carola⁵  Schultze-Mosgau, Stefan⁴  Stallmach, Andreas²  Kinne, Raimund W.¹  Wolf, Gunter³ 

[1] Univ Jena, Expt Rheumatol Unit, Univ Hosp Jena, Waldkrankenhaus Rudolf Elle Eisenberg,Dept Orthop, Jena, Germany

[2] Univ Jena, Dept Gastroenterol Hepatol & Infect Dis, Clin Internal Med 2, Univ Hosp Jena, Jena, Germany

[3] Univ Jena, Univ Hosp Jena, Clin Internal Med 3, Jena, Germany

[4] Univ Jena, Univ Hosp Jena, Clin Oromaxillofacial Surg Plast Surg, Jena, Germany

[5] Univ Jena, Univ Hosp Jena, Anim Res Inst, Jena, Germany

关键词: TGF-beta;    Fibrosis;    Arthritis;    Nephritis;    Inflammatory bowel disease;    Crohn's disease;    Wound-healing;    Myocarditis;   

DOI  :  10.1016/j.bbadis.2009.06.004

来源: Elsevier

【 摘 要 】

The action of transforming-growth-factor (TGF)-beta following inflammatory responses is characterized by increased production of extracellular matrix (ECM) components, as well as mesenchymal cell proliferation, migration, and accumulation. Thus, TGF-beta is important for the induction of fibrosis often associated with chronic phases of inflammatory diseases. This common feature of TGF-related pathologies is observed in many different organs. Therefore, in addition to the description of the common TGF-beta-pathway, this review focuses on TGF-beta-related pathogenetic effects in different pathologies/organs, i.e., arthritis, diabetic nephropathy, colitis/Crohn's disease, radiation-induced fibrosis, and myrocarditis (including their similarities and dissimilarities). However, TGF-beta exhibits both exacerbating and ameliorating features, depending on the phase of disease and the site of action. Due to its central role in severe fibrotic diseases, TGF-beta nevertheless remains an attractive therapeutic target, if targeted locally and during the fibrotic phase of disease. (C) 2009 Elsevier B.V. All rights reserved.

【 授权许可】

Free