Role of autophagy in inherited metabolic and endocrine myopathies

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1865

Review

Tan, Ying^1,2  Gong, Yan³  Dong, Maolong^1,2,4  Pei, Zhaohui³  Ren, Jun² 

[1] Southern Med Univ, Nanfang Hosp, Dept Emergency Med, Guangzhou 510515, Guangdong, Peoples R China

[2] Univ Wyoming, Coll Hlth Sci, Ctr Cardiovasc Res & Alternat Med, Laramie, WY 82071 USA

[3] Third Hosp Nanchang, Dept Cardiol 2, Nanchang 330009, Jiangxi, Peoples R China

[4] Southern Med Univ, Nanfang Hosp, Dept Burns, Guangzhou 510515, Guangdong, Peoples R China

关键词: Cardiometabolic diseases;    Autophagy;    Inherited myopathies;    Endocrine disorders;   

DOI  :  10.1016/j.bbadis.2018.10.023

来源: Elsevier

【 摘 要 】

The prevalence of cardiometabolic disease has reached an exponential rate of rise over the last decades owing to high fat/high caloric diet intake and satiety life style. Although the presence of dyslipidemia, insulin resistance, hypertension and obesity mainly contributes to the increased incidence of cardiometabolic diseases, population based, clinical and genetic studies have revealed a rather important role for inherited myopathies and endocrine disorders in the ever-rising metabolic anomalies. Inherited metabolic and endocrine diseases such as glycogen storage and lysosomal disorders have greatly contributed to the overall prevalence of cardiometabolic diseases. Recent evidence has demonstrated an essential role for proteotoxicity due to autophagy failure and/or dysregulation in the onset of inherited metabolic and endocrine disorders. Given the key role for autophagy in the degradation and removal of long-lived or injured proteins and organelles for the maintenance of cellular and organismal homeostasis, this mini-review will discuss the potential contribution of autophagy dysregulation in the pathogenesis of inherited myopathies and endocrine disorders, which greatly contribute to an overall rise in prevalence of cardiometabolic disorders. Molecular, clinical, and epidemiological aspects will be covered as well as the potential link between autophagy and metabolic anomalies thus target therapy may be engaged for these comorbidities.

【 授权许可】

Free