The versatile role of Serpina3c in physiological and pathological processes: a review of recent studies

Frontiers in Endocrinology

Endocrinology

Liang Guo¹  Yang Li¹ 

[1]School of Exercise and Health and Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, China

关键词: serine protease inhibitors;    cathepsin G;    thrombin;    Cardiometabolic diseases;    inflammation;    obesity;    insulin resistance;    NAFLD;   

DOI  :  10.3389/fendo.2023.1189007

 received in 2023-03-18, accepted in 2023-05-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

Murine Serpina3c belongs to the family of serine protease inhibitors (Serpins), clade “A” and its human homologue is SerpinA3. Serpina3c is involved in some physiological processes, including insulin secretion and adipogenesis. In the pathophysiological process, the deletion of Serpina3c leads to more severe metabolic disorders, such as aggravated non-alcoholic fatty liver disease (NAFLD), insulin resistance and obesity. In addition, Serpina3c can improve atherosclerosis and regulate cardiac remodeling after myocardial infarction. Many of these processes are directly or indirectly mediated by its inhibition of serine protease activity. Although its function has not been fully revealed, recent studies have shown its potential research value. Here, we aimed to summarize recent studies to provide a clearer view of the biological roles and the underlying mechanisms of Serpina3c.

【 授权许可】

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