Structural imaging in early pre-states of dementia

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1822

Review

Smith, Charles D.^1,2,3 

[1] Univ Kentucky, Chandler Med Ctr, Magnet Resonance Imaging Spect Ctr, Lexington, KY 40536 USA

[2] Univ Kentucky, Alzheimers Dis Ctr, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

[3] Univ Kentucky, Dept Neurol, Lexington, KY 40536 USA

关键词: Review;    Mild cognitive impairment;    Alzheimer's disease;    Magnetic resonance imaging;    Morphometry;    Normal aging;   

DOI  :  10.1016/j.bbadis.2011.07.002

来源: Elsevier

【 摘 要 】

In this review focus is on structural imaging in the Alzheimer's disease (AD) pre-states, particularly cognitively normal (CN) persons at future dementia risk. Findings in mild cognitive impairment (MCI) are described here only for comparison with CN. Cited literature evidence and commentary address issues of structural imaging alterations in CN that precede MCI and AD, regional patterns of such alterations, and the time relationship between structural imaging alterations and the appearance of symptoms of AD, issues relevant to the conduct of future AD prevention trials. This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease. (C) 2011 Elsevier B.V. All rights reserved.

【 授权许可】

Free