Non-selective cation channels, transient receptor potential channels and ischemic stroke

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1772

Review

Simard, J. Marc ; Tarasov, Kirill V. ; Gerzanich, Volodymyr

关键词: cation channel;    acid sensing ion channel;    NCCa-ATP channel;    transient receptor potential;    cerebral ischemia;    stroke;   

DOI  :  10.1016/j.bbadis.2007.03.004

来源: Elsevier

【 摘 要 】

Several pathways to neural cell death are involved in ischemic stroke, and all require monovalent or divalent cation influx, implicating nonselective cation (NC) channels. NC channels are also likely to be involved in the dysfunction of vascular endothelial cells that leads to fort-nation of ederna following cerebral ischemia. Two newly described NC channels have emerged as potential participants in ischemic stroke, the acid sensing ion channel (ASIC), and the sulfonylurea receptor-1 (SURI)-regulated NCCa-ATP channel. Non-specific blockers of NC channels, including pinokalant (LOE 908 MS) and rimonabant (SR141716A), have beneficial effects in rodent models of ischernic stroke. Evidence is accumulating that NC channels formed by members of the transient receptor potential (TRP) family are also up-regulated in ischernic stroke and may play a direct role in calcium-mediated neuronal death. The nascent field of NC channels, including TRP channels, in ischemic stroke is poised to provide novel mechanistic insights and therapeutic strategies for this often devastating human condition. (c) 2007 Elsevier B.V. All rights reserved.

【 授权许可】

Free