A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1792

Review

Cook, Casey¹  Petrucelli, Leonard¹ 

[1] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

关键词: Ubiquitin proteasome system;    Parkinson's disease;    Alpha-synuclein;    Ubiquitin ligase;    Substantia nigra;    Aggregation;    Parkin;    Lewy bodies;    DJ-1;    Leucine-rich repeat kinase 2;   

DOI  :  10.1016/j.bbadis.2009.01.012

来源: Elsevier

【 摘 要 】

The evidence for impairment in the ubiquitin proteasome system (UPS) in Parkinson's disease (PD) is mounting and becoming increasingly more convincing. However, it is presently unclear whether UPS dysfunction is a cause or result of PD pathology, a crucial distinction which impedes both the understanding of disease pathogenesis and the development of effectual therapeutic approaches. Recent findings discussed within this review offer new insight and provide direction for future research to conclusively resolve this debate. (C) 2009 Elsevier B.V. All rights reserved.

【 授权许可】

Free