Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1842

Review

Gan, Li¹  Johnson, Jeffrey A.^1,2,3,4 

[1] Univ Wisconsin, Sch Pharm, Madison, WI 53705 USA

[2] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA

[3] Univ Wisconsin, Mol & Environm Toxicol Ctr, Madison, WI 53705 USA

[4] Univ Wisconsin, Ctr Neurosci, Madison, WI 53705 USA

关键词: Oxidative stress;    Nrf2-ARE pathway;    Misfolded proteins;    Neurodegenerative diseases;   

DOI  :  10.1016/j.bbadis.2013.12.011

来源: Elsevier

【 摘 要 】

Oxidative damage contributes to pathogenesis in many neurodegenerative diseases. As the indicator and regulator of oxidative stress, the Nrf2-ARE pathway has been shown dynamic changes and examined for its neuroprotective role in many cases. In this review, we summarize the progress of the Nrf2-ARE pathway in combating toxicity induced from typical misfolded protein aggregates in neurodegenerative diseases, and specifically the effects on the clearance of protein aggregates. This article is part of a Special Issue entitled: Misfolded Proteins, Mitochondrial Dysfunction, and Neurodegenerative Diseases. (C) 2013 Published by Elsevier B.V.

【 授权许可】

Free