The role of obesity in inflammatory bowel disease

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1865

Review

Kreuter, Roxane¹  Wankell, Miriam¹  Ahlenstiel, Golo^2,3,4  Hebbard, Lionel^1,2,3 

[1] James Cook Univ, Australian Inst Trop Hlth & Med, Ctr Mol Therapeut, Dept Mol & Cell Biol, Townsville, Qld 4811, Australia

[2] Westmead Hosp, Westmead Inst Med Res, Storr Liver Ctr, Sydney, NSW 2145, Australia

[3] Univ Sydney, Sydney, NSW 2145, Australia

[4] Western Sydney Univ, Blacktown Hosp, Blacktown Clin Sch, POB 792, Seven Hills, NSW 2147, Australia

关键词: Adipocytokines;    Adiponectin;    Inflammation;    Bowel disease;   

DOI  :  10.1016/j.bbadis.2018.10.020

来源: Elsevier

【 摘 要 】

In just over a generation overweight and obesity has become a worldwide health concern. The ramifications for this on future health care costs and longevity are consequent, whilst increased adiposity is a harbinger for diabetes, kidney and bone failure, and cancer. An area of intense interest where the role of adiposity is avidly discussed is in inflammatory bowel disease (IBD), which presents mainly as Crohn's disease (CD) and ulcerative colitis (UC). Studies in patients associating IBD with a western diet are divergent. Nevertheless, elegant studies have found gene polymorphisms in humans that in murine models parallel the inflammatory and gut micro-biome changes seen in IBD patients. However, an area not to be ignored are the alterations in adipocyte function with ensuing adiposity, in particular and a focus of this review, the dysregulation of the levels of adipocytokines such as leptin and adiponectin. Herein, we present and discuss the known influences of a western diet on IBD in patients and rodent models and how adipocytokines could influence the IBD disease process.

【 授权许可】

Free