Mitochondria-targeted antioxidants for treatment of Parkinson's disease: Preclinical and clinical outcomes

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1842

Review

Jin, Huajun¹  Kanthasamy, Arthi¹  Ghosh, Anamitra¹  Anantharam, Vellareddy¹  Kalyanaraman, Balaraman²  Kanthasamy, Anumantha G.¹ 

[1] Iowa State Univ, Dept Biomed Sci, Iowa Ctr Adv Neurotoxicol, Parkinsons Disorder Res Lab, Ames, IA 50011 USA

[2] Med Coll Wisconsin, Free Radical Res Ctr, Dept Biophys, Milwaukee, WI 53226 USA

关键词: Mitochondrial dysfunction;    Mitochondria-targeted antioxidant;    Neuroprotection;    Oxidative stress;    Parkinson's disease;   

DOI  :  10.1016/j.bbadis.2013.09.007

来源: Elsevier

【 摘 要 】

Parkinson's disease is a progressive neurodegenerative disease in the elderly, and no cure or disease-modifying therapies exist. Several lines of evidence suggest that mitochondrial dysfunction and oxidative stress have a central role in the dopaminergic neurodegeneration of Parkinson's disease. In this context, mitochondria-targeted therapies that improve mitochondrial function may have great promise in the prevention and treatment of Parkinson's disease. In this review, we discuss the recent developments in mitochondria-targeted antioxidants and their potential beneficial effects as a therapy for ameliorating mitochondrial dysfunction in Parkinson's disease. This article is part of a Special Issue entitled: Misfolded Proteins, Mitochondrial Dysfunction, and Neurodegenerative Diseases. (C) 2013 Elsevier B.V. All rights reserved.

【 授权许可】

Free