Immune-neuroendocrine and metabolic disorders in human and experimental T. cruzi infection: New clues for understanding Chagas disease pathology

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1866

Review

Gonzalez, Florencia B.¹  Villar, Silvina R.¹  Florencia Pacini, M.¹  Bottasso, Oscar A.¹  Perez, Ana R.¹ 

[1] UNR, CONICET, IDICER, Inst Clin & Expt Immunol Rosario, Rosario, Argentina

关键词: Hypothalamus-pituitary-adrenal axis;    Glucocorticoids;    PPAR-gamma;    Adipose tissue;    IL-1 beta;    Chagas disease;   

DOI  :  10.1016/j.bbadis.2019.165642

来源: Elsevier

【 摘 要 】

Studies in mice undergoing acute Trypanosoma cruzi infection and patients with Chagas disease, led to identify several immune-neuroendocrine disturbances and metabolic disorders. Here, we review relevant findings concerning such abnormalities and discuss their possible influence on disease physiopathology.

【 授权许可】

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