The plasminogen activation system in neuroinflammation

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1862

Article

Docagne, Fabian¹ 

[1] Univ Caen Basse Normandie, INSERM, Serine Proteases & Pathophysiol Neurovasc Unit U9, Caen, France

关键词: Plasminogen activator;    Blood-brain barrier;    Leukocytes;    Microglia;   

DOI  :  10.1016/j.bbadis.2015.10.011

来源: Elsevier

【 摘 要 】

The plasminogen activation (PA) system consists in a group of proteases and protease inhibitors regulating the activation of the zymogen plasminogen into its proteolytically active form, plasmin. Here, we give an update of the current knowledge about the role of the PA system on different aspects of neuroinflammation. These include modification in blood-brain barrier integrity, leukocyte diapedesis, removal of fibrin deposits in nervous tissues, microglial activation and neutrophil functions. Furthermore, we focus on the molecular mechanisms (some of them independent of plasmin generation and even of proteolysis) and target receptors responsible for these effects. The description of these mechanisms of action may help designing new therapeutic strategies targeting the expression, activity and molecular mediators of the PA system in neurological disorders involving neuroinflammatory processes. This article is part of a Special Issue entitled: Neuro Inflammation edited by Helga E. de Vries and Markus Schwaninger. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

Free