Making waves: Wastewater-based epidemiology for COVID-19-approaches and challenges for surveillance and prediction

WATER RESEARCH

卷:186

Article

Polo, David^1,2  Quintela-Baluja, Marcos³  Corbishley, Alexander^4,5  Jones, Davey L.^6,7  Singer, Andrew C.⁸  Graham, David W.³  Romalde, Jesus L.^1,2 

[1] Univ Santiago de Compostela, Fac Biol, CIBUS, Dept Microbiol & Parasitol, Santiago De Compostela 15782, Spain

[2] Univ Santiago de Compostela, Inst CRETUS, Santiago De Compostela 15782, Spain

[3] Newcastle Univ, Sch Engn, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[4] Univ Edinburgh, Roslin Inst, Easter Bush Campus, Roslin EH25 9RG, Midlothian, Scotland

[5] Univ Edinburgh, Royal Dick Sch Vet Studies, Easter Bush Campus, Roslin EH25 9RG, Midlothian, Scotland

[6] Bangor Univ, Environm Ctr Wales, Bangor LL57 2UW, Gwynedd, Wales

[7] Univ Western Australia, UWA Sch Agr & Environm, Perth, WA 6009, Australia

[8] UK Ctr Ecol & Hydrol, Wallingford OX10 8BB, Oxon, England

关键词: Wastewater-based epidemiology;    Environmental monitoring;    Coronavirus;    SARS-CoV-2;    COVID-19;    Sewage;   

DOI  :  10.1016/j.watres.2020.116404

来源: Elsevier

【 摘 要 】

The presence of SARS-CoV-2 in the feces of infected patients and wastewater has drawn attention, not only to the possibility of fecal-oral transmission but also to the use of wastewater as an epidemiological tool. The COVID-19 pandemic has highlighted problems in evaluating the epidemiological scope of the disease using classical surveillance approaches, due to a lack of diagnostic capacity, and their application to only a small proportion of the population. As in previous pandemics, statistics, particularly the proportion of the population infected, are believed to be widely underestimated. Furthermore, analysis of only clinical samples cannot predict outbreaks in a timely manner or easily capture asymptomatic carriers. Threfore, community-scale surveillance, including wastewater-based epidemiology, can bridge the broader community and the clinic, becoming a valuable indirect epidemiological prediction tool for SARS-CoV-2 and other pandemic viruses. This article summarizes current knowledge and discusses the critical factors for implementing wastewater-based epidemiology of COVID-19. (c) 2020 The Authors. Published by Elsevier Ltd.

【 授权许可】

Free