Selective synthesis of either enantiomer of an anti-breast cancer agent via a common enantioenriched intermediate

TETRAHEDRON LETTERS

卷:56

Article

Johnson, Aaron George¹  Tranquilli, Marissa M.¹  Harris, Michael R.¹  Jarvo, Elizabeth R.¹ 

[1] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA

关键词: Nickel;    Cross-coupling;    Stereospecific;    Anti-cancer agent;    Triarylmethane;   

DOI  :  10.1016/j.tetlet.2015.02.121

来源: Elsevier

【 摘 要 】

A stereoselective synthesis of a bioactive triarylmethane is described. Key to the synthesis is a nickel-catalyzed Suzuki-Miyaura coupling which proceeds with retention at the benzylic center. This method is complementary to our previously reported nickel-catalyzed Kumada coupling which proceeds with inversion. Together, the two methods allow for efficient access to either enantiomer of biologically relevant triarylmethanes from a common enantioenriched intermediate. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

Free