Cross-coupling reactions by cooperative Pd/Cu or Ni/Cu catalysis based on the catalytic generation of organocopper nucleophiles

TETRAHEDRON

卷:75

Article

Semba, Kazuhiko¹  Nakao, Yoshiaki¹ 

[1] Kyoto Univ, Grad Sch Engn, Dept Chem Mat, Nishikyo Ku, Kyoto 6158510, Japan

关键词: Cooperative catalysis;    Cross-coupling;    Palladium;    Nickel;    Copper;   

DOI  :  10.1016/j.tet.2018.12.013

来源: Elsevier

【 摘 要 】

In this review, cross-coupling reactions by cooperative Pd/Cu or Ni/Cu catalysis based on catalytically generated organocopper nucleophiles are summarized. Compared to conventional methods based on the use of stoichiometric amounts of pre-synthesized organometallic reagents, these methods are powerful tools for the alkynylation, arylation, alkenylation, and alkylation of organic electrophiles, especially as they can be carried out in a highly step-economical manner with readily available starting materials based on simple arenes, carboxylic acids, alkenes, and alkynes as pre-nucleophiles. (C) 2018 Elsevier Ltd. All rights reserved.

【 授权许可】

Free