Synthetic studies toward bryostatin 1:: preparation of a C1-C16 fragment by pyran annulation

TETRAHEDRON LETTERS

卷:47

Article

Keck, Gary E. ; Welch, Dennie S. ; Poudel, Yam B.

关键词: bryostatin;    chelation;    allylation;    stannane;   

DOI  :  10.1016/j.tetlet.2006.09.094

来源: Elsevier

【 摘 要 】

An expeditious assembly of a C-1-C-16 Subunit of bryostatin I is described. A pyran annulation reaction was utilized to form the B-ring by reaction of a hydroxy-allylsilane with a fully elaborated A-ring subunit. This annulation process proceeded with complete diastereoselectivity and in excellent isolated yield despite the presence of potentially sensitive functionality in the A-ring segment. (c) 2006 Elsevier Ltd. All rights reserved.

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