An efficient transformation of ethers to N,N′-disubstituted ureas in a Ritter type reaction

TETRAHEDRON LETTERS

卷:54

Article

Panduranga, Veladi¹  Basavaprabhu¹  Sureshbabu, Vommina V.¹ 

[1] Bangalore Univ, Peptide Res Lab, Dept Studies Chem, Dr BR Ambedkar Veedhi, Bangalore 560001, Karnataka, India

关键词: Cyanamides;    Ethers;    Lewis acid;    N,N '-disubstituted ureas;   

DOI  :  10.1016/j.tetlet.2012.12.027

来源: Elsevier

【 摘 要 】

A simple, mild, and an alternative protocol for the preparation of N,N'-disubstituted ureas from readily available ethers and cyanamides as starting materials is described. The protocol explores the reactivity of ether in a Ritter type reaction with cyanamide in the presence of BF3 center dot Et2O and resulting in the formation of N,N'-disubstituted urea. Divinyl ether as well as MTBE (methyl tert-butyl ether) can be employed as ether components to afford allyl and tert-butyl ureas respectively. (C) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

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