期刊论文详细信息
TETRAHEDRON LETTERS | 卷:54 |
Hydrophilic pyrazine-based phosphane ligands: synthesis and application in asymmetric hydride transfer and H2-hydrogenation of acetophenone | |
Article | |
Nikishkin, Nicolai I.1  Huskens, Jurriaan1  Verboom, Willem1  | |
[1] Univ Twente, MESA Inst Nanotechnol, Lab Mol Nanofabricat, NL-7500 AE Enschede, Netherlands | |
关键词: Asymmetric catalysis; Hydrogenation; Phosphanes; Pyrazine; Reduction; | |
DOI : 10.1016/j.tetlet.2013.01.108 | |
来源: Elsevier | |
【 摘 要 】
Pyrazine-based hydrophilic phosphanes are useful ligands for the ruthenium- and rhodium-catalyzed hydrogenations of acetophenone under hydride transfer and dihydrogen conditions. The effect of alcohol additives on the catalytic, enantioselective aqueous hydrogenation of acetophenone is examined with the newly developed (R,R)-DAMPYPHOS as the ligand and Rh-2(norbornadiene)(2)Cl-2 as the catalyst precursor, giving rise to higher conversions (up to quantitative) and improved enantiomeric excesses (up to 95%) of the formed 1-phenylethanol. (C) 2013 Elsevier Ltd. All rights reserved.
【 授权许可】
Free
【 预 览 】
Files | Size | Format | View |
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10_1016_j_tetlet_2013_01_108.pdf | 476KB | download |