Intramolecular cyclization strategies toward the synthesis of zoanthamine alkaloids

TETRAHEDRON LETTERS

卷:52

Article

Fischer, Derek¹  Nguyen, Thong X.¹  Trzoss, Lynnie¹  Dakanali, Marianna¹  Theodorakis, Emmanuel A.¹ 

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

关键词: Zoanthamine;    Cycloaddition;    Aminodiene;    Stille coupling;    Diels-Alder reaction;   

DOI  :  10.1016/j.tetlet.2011.07.054

来源: Elsevier

【 摘 要 】

Stabilized 2-amino-1,3-dienes can participate in intramolecular Diels-Alder (IMDA) reactions with pendant dienophiles. We found that these dienes can be readily prepared via standard palladium-mediated coupling reactions and have comparable reactivity to 2-oxodienes. Application of these substrates to the synthesis of tetracyclic model systems representing the ABCE motif of the zoanthamines is presented. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

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