Pd0-Catalyzed Methyl Transfer on Nucleosides and Oligonucleotides, Envisaged as a PET Tracer

Molecules

Damien James¹  Jean-Marc Escudier²  Magali Szlosek-Pinaud¹ 

[1] Institut des Sciences Moléculaires, Université de Bordeaux, UMR5255, 351 Cours de la Libération, Talence 33405, France; E-Mail:;Laboratoire de Synthèse et Physicochimie- de Molécules d’Intérêt Biologique, Université Paul Sabatier, UMR5068, 118 route de Narbonne, Toulouse 31062, France; E-Mail:

关键词: Stille coupling;    nucleosides;    oligonucleotides;    methyl transfer;    Positron Emission Tomography;   

DOI  :  10.3390/molecules181113654

来源: mdpi

【 摘 要 】

The methyl transfer reaction from activated monomethyltin, via a modified Stille coupling reaction, was studied under “ligandless” conditions on fully deprotected 5'-modified nucleosides and one dinucleotide. The reaction was optimized to proceed in a few minutes and quantitative yield, even under dilute conditions, thus affording a rapid and efficient new method for oligonucleotide labelling with carbon-11.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.